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Studies have shown that approximately 2% to 4% of individuals may have adverse reactions to collagen derived from bovine or porcine sources

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4,11,15 Inflammatory responses mediated by proinflammatory cytokines and pathways, such as nuclear factor kappa B (NF-B) and Toll-like receptor 4 (TLR4), worsen the condition by amplifying oxidative stress and hindering neuronal repair