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Liver slices from mice exhibited marked liver injury when incubated with acetaminophen, which was accompanied by extensive metabolism of the drug and by glutathione conjugate formation (demonstrating that metabolic bioactivation had occurred), while mouse liver slices that were incubated with equivalent doses of AMAP exhibited a markedly reduced extent of injury and did not generate detectable levels of glutathione conjugates

Chronic daily administration of cotadutide over 27 days in obese mice was associated with food intake reduction, decreased adiposity, improved fasting glucose, and increased energy expenditure

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