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Data Charting Relevant information from each included study was extracted using a data charting form that captured the following fields: author(s), year of publication, country of origin, whether the combination was an add-on or simultaneously used, study population characteristics relevant to the outcomes, and sample size, study design, intervention or exposition type and details of these, comparator, outcomes and their specifics, adverse effects reports, and key findings related to the scoping review questions

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While MS was initially suspected, given the history of optic neuritis and paresthesia, this diagnosis was ruled out on the basis of normal MRI findings and the absence of spinal cord involvement or demyelinating lesions