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Cellular physiology in response to nicotine Following inhalation of tobacco smoke, nicotine is absorbed mainly by small airways and alveoli of the lungs, and the residue is distributed throughout the body by the circulatory system and alters the physiological processes of cells that express nAChRs

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(Interview with Kirk Hammett) In fact, if you consider that the reason why Nirvana suddenly took off was because rock kids who were tired of the soft and strong guitar tones of pop metal were crazy about Cobain's high-gain distorted guitar tone, it is true that the thrash metal band Metallica had some influence on Nirvana.[30] For reference, if you look at Korean media in the 90s, Nirvana was incorrectly introduced as a heavy metal band, and this sound may have made it sound quite similar to heavy metal to an outsider