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and (3) early oxyntomodulin analogs, which were discontinued in part because regulatory endpoints for combination receptor agonism had not yet been established ( 8.1 Regulatory expectations and evidence standards Regulatory agencies increasingly emphasize mechanism-anchored development supported by robust pharmacodynamic biomarkers and clinically meaningful endpoints ( A recurring integrity issue in peptide development has been premature extrapolation from animal models to humans

It took until today, nearly four months later, for regulators to conclude that the drug was widely available enough to remove it from the shortage list

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Seizure disorders - Patients who have a history of seizures should avoid bupropion