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Lancet Oncol 13(11):11611170 Moore MJ et al (2007) Erlotinib plus gemcitabine compared with gemcitabine alone in patients with advanced pancreatic cancer: a phase III trial of the National Cancer Institute of Canada Clinical Trials Group

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29 This approach was utilized in this study to evaluate whether BDNF knockdown in specific hippocampal subregions can actually affect behaviors associated with depression and whether such a localized reduction in the BDNF protein can affect neurogenesis in vivo