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Manufacturers want broader access without giving up too much pricing power

Excess body weight puts stress on the joints, increasing risk of fractures, but weight loss from calorie restriction is associated with reductions in bone mineral density (BMD) with increased bone turnover

But the warning flags are based on well-established cancer biology: FAK signaling is a known driver of tumor aggressiveness, and VEGF pathways are active in more than half of all solid tumors

Clinical Observations and Evidence Recent clinical data published in the New England Journal of Medicine demonstrated that standard-dose semaglutide administration resulted in an average 15% reduction in body weight over 68 weeks