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While theres no definite cutoff for when B12 starts to become unsafe, because people often ask, well somewhat arbitrarily say not to take more than 1,000 g per day over the long-term without guidance from a physician

Vitamin B6 has the ability to improve metabolism and the breakdown of protein

Important considerations include: Limited long-term human data Individual variability in response Potential side effects Need for ongoing medical supervision Because research continues to evolve, realistic expectations are essential

Remember that early diagnosis and treatment offer the best chance of reversing nerve damage, so prompt medical consultation is always advisable when concerning symptoms develop