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Int Jr of Dermatology 2021 Topical and oral glutathione were effective skin-lightening agents

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A reduction in the levels of GSH, and consequently of antioxidant defenses, may increase the risk of damage to the host via transcription factor activation leading to up-regulation of proinflammatory cytokines, such as nuclear transcription factors and activator proteins, induced in turn by agents such as hydrogen peroxide, mitogens, bacteria, viruses, and UV and ionizing radiation

Five to six eating occasions of 200-350 calories each typically work better than three 500+ calorie meals