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Keywords MC4R deficiency , genetic obesity , GLP-1 receptor agonists , leptin-melanocortin pathway , weight management 0 1 INTRODUCTION Genetic obesity is broadly divided into syndromic obesity and non-syndromic obesity, both of which can be caused by monogenic, polygenic, or chromosomal abnormalities [1]

Originally developed for type 2 diabetes and obesity, GLP-1 agonists such as semaglutide and liraglutide are now being investigated for their potential effects on alcohol consumption

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Moreover, bone microarchitecture/strength changes assessed by high-resolution peripheral quantitative computed tomography (HR-pQCT) are lacking