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Laugier-Hunziker syndrome: a case report and review of the literature

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namely, maximal (1 M agonist) cAMP production increased as maximal internalization fell, but reached a plateau beyond which further decrease in internalization did not yield additional increase in cAMP efficacy

In an autoimmune context, these responses can cascade into thyroid flares, increased antibody activity, and deepened fatigue that takes weeks to recover from