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4.2 Potential impact of gut microbiota on ferroptosis in OA 4.2.1 Gut dysbiosis promotes lipid peroxidation and ferroptosis in OA In patients with OA, the significant dysregulation of the gut microbiota not only manifests as a disorder in the community structure but also profoundly affects the pathological process of OA by precisely regulating the key hub genes in the host lipid metabolism network

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If these agents also improve triglycerides, waist circumference, blood pressure, inflammation, and insulin resistance, they may become comprehensive cardiometabolic therapies rather than weight-loss drugs alone