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They are classified as: First-generation (sedating): Chlorphenamine (Piriton), promethazine these cross the blood-brain barrier and commonly cause drowsiness [24] [25] Second-generation (non-sedating): Cetirizine (Zirtek), loratadine (Clarityn), fexofenadine (Telfast) these have a lower sedative profile and are generally preferred for daytime use Intranasal corticosteroids such as fluticasone (Flixonase) and beclometasone (Beconase) are recommended by NICE CKS (Allergic rhinitis) as first-line treatment for moderate-to-severe allergic rhinitis

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FDA , 4:25-cv-00174 (N.D