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This cascade leads to upregulation of tyrosinase and other enzymes involved in melanin biosynthesis in cell culture models

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The preliminary cardiovascular safety data for DPP-4 inhibitors are promising, and, if the results of long-term cardiovascular studies demonstrate reductions in hard cardiovascular end points, then this may consolidate the position of the DPP-4 inhibitors as the second-line choice for combination with metformin

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