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After the introduction of various tricyclics and selective serotonin re-uptake inhibitors (SSRIs), two competing ideas on the action of antidepressants became current, given the observed effectiveness of antidepressants only on chronic use: receptor desensitization and the modulation of second messenger systems (Feighner, 1999)

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The dura mater is sutured with an artificial dural patch and reinforced with bioglue