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Figure 8 Discussion A growing evidence has suggested that regulated necrosis could induce numerous inflammation and serves as a therapeutic target of AKI ( Lipoic acid is a well-known antioxidative agent that can be used clinically to treat DM and neurodegenerative diseases, closely related to reducing the risk of occurrence of complication and mortality ( via anti-inflammation ( + /K + -ATPase

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Injection site reactions are the most common skin-related side effects, presenting as localized redness, swelling, bruising, or itching at the injection site

The December 2025 Phase 3 TRIUMPH-4 results were even more impressive, with the 12mg group losing an average of 28.7% of body weight over 68 weeks