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NPY also plays a role in the neuroimmune crosstalk as evidenced by the fact that it is also produced by immune cells in response to activation and as a result modulates several immunological functions such as chemotaxis, T cell differentiation, antigen presenting cell function, leukocyte migration, neutrophil respiratory burst, and phagocytosis by binding to different Y receptor subtypes

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Similar results were reported by Wang et al., where GLP-1 RA treatment had a notable impact on the abundance of weight-related microbial phylotypes, though no significant change in the Firmicutes/Bacteroidetes ratio was observed (72)

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