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A PHGDH inhibitor reveals coordination of serine synthesis and one-carbon unit fate

, 4 , 2179-2185, Hu, X.-Q., Chu, J., Zhang, S.-L., Zhuang, Y.-P., Wang, Y.-H., Zhu, S., Zhu, Z.-G., and Yuan, Z.-Y

In the brains of Alzheimers disease (AD) patients, pathological features such as reduced mitochondrial membrane potential (m), accumulation of mitochondrial peroxides, aberrant opening of the mitochondrial permeability transition pore (mPTP), and mitochondrial iron (mFe) overload are commonly observedeach closely linked to ferroptosis induction (Chen et al., 2023

Design, Setting, Participants This is a phase II, randomized, multi-center, double-blind, placebo-controlled trial among 60 participants with mild cognitive impairment or dementia due to AD