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Treatment with palmitic acid leads to a doubling in oxygen uptake rate at early stage and overproduction of reactive oxygen species (ROS), which causes oxidative modification of proteins and lipids and/or disrupts signaling pathways via inactivation of phosphatases [67]
10-13,29 IBTs have also been associated with sarcopenia or loss of lean muscle mass, particularly in older adults, frail individuals, and those with chronic comorbid conditions
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