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The composite is injected subcutaneously into the tumor region before surgery, and after near-infrared (NIR) activation, the nanorobots self-propel into the deep tumor, releasing thrombin on demand to embolize the tumors blood supply

While treatment-emergent HLA antibodies are likely to be reduced by the use of leukocyte-reduced RBCs in both Test and Control arms, we hypothesize that inactivation of residual leukocytes by the amustaline/GSH pathogen reduction process might affect the incidence of alloimmunization