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A clinical series published in the Journal of Clinical Medicine found that patients with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) who received intermittent intravenous saline infusions over a 9-week period showed beneficial effects in managing symptoms of dysautonomia and postural orthostatic tachycardia syndrome (POTS)

This lengthy process commonly known as the "Correa pathway" is dependent on continued or chronic inflammation (110, 111)

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Besides the direct cytotoxic and prooxidant effects of CP treatment, necroptosis could be induced indirectly through the combined action of cytokines, TNF-, TNF-related weak inducer of apoptosis, and IFN-, which were upregulated upon CP administration