The Pritikin Approach to Supporting GLP-1 and GIP Medication Users Integrating Diet and Lifestyle Changes At Pritikin, we believe that medication alone is not enough for sustainable weight loss and health improvement

Disclosures: Nikia Smith: Nothing to Disclose, Cynthia Moylan: GSK: Grant/Research Support, Madrigal Pharmaceuticals: Grant/Research Support, Exact Sciences: Grant/Research Support, Sirtex: Advisor, NovoNordisk: Consultant, Gina Austin: Nothing to Disclose, Adriana Vidal: Nothing to Disclose, Yukun Liu: Nothing to Disclose, Susan Murphy: Nothing to Disclose, Joellen Schildkraut: Nothing to Disclose, Jeffrey Enders: Nothing to Disclose, Antonio Planchart: Nothing to Disclose, Cathrine Hoyo: Nothing to Disclose 1742 THE OTAGO EXERCISE PROGRAM IMPROVES LIVER FRAILTY IN PRE-TRANSPLANT CANDIDATES Neil Shah 1 Kathryn Bridgens 2 Jyotsna Gupta 1 Deborah Givens 1 , 1 University of North Carolina at Chapel Hill School of Medicine, 2 UNC Health Background: Outpatient pre-habilitation has effectively improved the frailty of candidates for liver transplant (LT)

Disclosures: Qian Xue: Nothing to Disclose, Liang Deng: Nothing to Disclose, Jinqiu Zhao: Nothing to Disclose, Fengling Peng: Nothing to Disclose, Youping Zhou: Nothing to Disclose, Li Zhong: Nothing to Disclose, Lu Huang: Nothing to Disclose, Shan Li: Nothing to Disclose, Chunhong Guo: Nothing to Disclose 2007 HUC-MSCS EXOSOME-DERIVED MIR-100-5P ALLEVIATES LIVER FIBROSIS BY INDUCING AUTOPHAGIC DEATH OF HEPATIC STELLATE CELLS yonghong wang 1 Menglan Wang 1 Yachao Tao 1 dongbo wu 1 enqiang Chen 1 hong Tang 1 , 1 West China hospital, Sichuan University Background: The incidence of end-stage liver disease is very high in the late stage of liver fibrosis,so early treatment of liver fibrosis is of great significance

Disclosures: Iyiad Alabdul Razzak: Nothing to Disclose, Gloria Horta: Nothing to Disclose, Xinyuan Zhang: Nothing to Disclose, Paolo Lopedote: Nothing to Disclose, Xuehong Zhang: Nothing to Disclose, Michelle Lai: Nothing to Disclose 2283 THE FRAILTY COMPONENT OF HEPATIC ENCEPHALOPATHY - EXPLORING PHYSICAL AND COGNITIVE FUNCTION IN ADVANCED CHRONIC LIVER DISEASE Andres Duarte-Rojo 1 Miguel Sogbe 2 Randi Wong 3 Robert Rahimi 4 Pamela Bloomer 5 Alexandra Steinberg 6 Jennifer Lai 3 , 1 Northwestern Medicine, 2 Universidad de Navarra, 3 UCSF, 4 Baylor University Medical Center, 5 UPMC, 6 Axcella Health, Inc Background: Physical frailty and minimal hepatic encephalopathy (MHE) are common in advanced chronic liver disease (AdvCLD)