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inhibiting NOX4 using drugs and inhibitors may improve DES (110)

It was found that DA can inhibit lipopolysaccharide (LPS)-induced activation of NLRP3 inflammasome and subsequent production of caspase-1 and IL-1 in a time- and dose-dependent manner through G protein pathway and -arrestindependent pathway ( Figure 1 )

The extent and clinical significance of this effect remain subjects of ongoing investigation, and individual responses vary considerably based on genetic factors affecting pigmentation, baseline skin characteristics, concurrent skincare practices and sun exposure, and overall health status affecting skin appearance

xCT: cystine/glutamate antiporter SLC7A11