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Also, mouse models of PD have indicated decreased NRF2 activity in astrocytes (Chen et al., 2009) and knockdown of NRF2 has been shown to cause an increase in mitochondrial ROS production (Kovac et al., 2015), the loss of dopaminergic neurons in association with microglia activation (Rojo et al., 2010) and exacerbation of synuclein aggregation (Lastres-Becker et al., 2012)

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