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One of the most widely studied dietary interventions is Mediterranean Diet (MedDiet), characterized by a combination of high complex carbohydrates rich in fiber (vegetables, fruits, cereals and legumes), polyunsaturated fatty acids like omega-3 polyunsaturated fatty acids (PUFAs) or monounsaturated fatty acids (MUFA) with antiatherogenic and anti-inflammatory properties (found in olive oil, fish, seafood and nuts), and bioactive compounds found in plants with antioxidative properties such as flavonoids, phytosterols, terpenes and polyphenols

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Therefore, ideal cell-free hydrogel scaffolds for cartilage repair should feature the following advantages: the capability for minimally invasive surgery, adequate tissue adhesiveness for local fixation, similar mechanical strength to cartilage tissue, stem cell recruitment, and chondrocyte differentiation