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90 In a 12-week trial in 15 overweight or obese adults who were 36 years old on average, 500 mg twice daily of this same high-tannin extract had a significant beneficial impact on markers of cardiovascular risk

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Escalating every 2 weeks might seem like it will get you to the effective dose faster, but it dramatically increases the risk of severe nausea, vomiting, and diarrhea that could force you to stop entirely