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Laboratory studies have demonstrated biological activity at concentrations as low as 0.01 nanomolar, showing measurable effects on fibroblast activity and collagen production even at these minute levels

J Cardiovasc Pharmacol 54:391398 Ghibu S, Delemasure S, Richard C, Guilland JC, Martin L, Gambert S, Rochette L, Vergely C (2012) General oxidative stress during doxorubicin-induced cardiotoxicity in rats: absence of cardioprotection and low antioxidant efficiency of alpha-lipoic acid

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Cold Spring Harb Perspect Biol 10.1101/cshperspect.a040592 [DOI] [PMC free article] [PubMed] [Google Scholar] *.Chandel NS