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Semaglutide, a GLP-1 receptor agonist originally developed for type 2 diabetes, has become a leading weight loss medication used by millions of people seeking sustainable body composition changes

How peripherally administered GLP-1 induces satiety mechanistically is unclear, but it is postulated that signals being generated by the binding of GLP-1 to its receptor on neurons in the GIT, hepatoportal bed and CNS mediate this effect

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In addition, although nonsignificant, findings from our pooled analysis suggest a trend favoring the use of GTR alone or STR with radiation therapy over STR alone