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Science 366 , 818822 (2019)

And, of the 20 million adults in the US who suffer from severe obesity, less than 1% will undergo bariatric surgery annually

Concurrently, downregulation of STAMBP and NEP may impair protein clearance mechanisms, exacerbating proteotoxic stress and -amyloid (A) deposition [52], ultimately triggering neuronal apoptosis, which aligns with our previous observation of reduced MAP2-positive neurons

Coppin JP, Xu Y, Chen H, Pan MH, Ho CT, Juliani R, Simon JE, Wu Q