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For patients without absorption disorders, high-dose oral supplements of 1,000 to 2,000 mcg daily have been shown to be comparably effective at correcting mild to moderate deficiency at lower cost and greater convenience.

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Thereby, it can counteract agitation before muscle disability, numerous twitches before complete loss of muscle tone, motionless prostration, and, subsequently, a painful reaction (violent screaming upon light touch) [81]

This attention to detail is for researchers in controlled lab settings