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High heart rate: a cardiovascular risk factor

54,55 Functionally, these classes of drugs strongly and selectively inhibit reabsorption of glucose by renal SGLT-2, thereby resulting in glucosuria, and rearrangement of bodily hemodynamics, such as reduction of arterial blood pressure, depletion of interstitial fluid rather than blood volume that improves both preload and afterload in heart failure, and neuroendocrine factors like the RAAS system

The 2% and 5% topical formulations require no prescription, though higher concentrations or oral formulations fall under different regulatory categories

This discovery sparked interest in using the drug specifically for weight management, leading to the development of higher-dose versions designed for this purpose