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Wnt/-catenin signaling is thought to be the main initiating driver of taste placode development

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This activates protein kinase A (PKA), a key player in GH synthesis

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Notably, in animal (rodent) models of schizophrenia and autism, maternal infection with the H1N1 virus results in prenatal alterations in the genes of the offspring which include changes to GRIK2 and GABAergic genes leading to structural changes in the brain and adverse effects on behaviour (Hossein Fatemi, Powerpoint presentation, 2011)

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