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10.3389/fphys.2022.967104 258 ZhangM

To test this, we inhibited the cysteine/glutamate antiporter System Xc - using Imidazole Ketone Erastin (IKE), thereby limiting substrate availability for GSH synthesis ( Figure 6H )

The proteasome inhibitor bortezomib drastically affects inflammation and bone disease in adjuvantinduced arthritis in rats

These behavioral benefits are underpinned by its marked ability to induce spinogenesis and promote functional synaptogenesis in hippocampal neurons, highlighting its potential as a robust procognitive and antidementia agent [2]