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These gastrointestinal effects often resolve within 710 days of dose adjustment, but if they persist beyond 2 weeks, increasing the dose further can worsen symptoms

doi: 10.1038/s41423-020-0472-1 173 KansalRRichardsonNNeeliIKhawajaSChamberlainDGhaniMet al

With patients able to increase their ability to walk pain-free for longer distances

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