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Abdelhafiz AH, Rodrguez-Maas L, Morley JE, Sinclair AJ

Pyrrolidine (artemisinin synthetic drug) can upregulate DR5 expression by activating JNK, triggering the TRAIL-induced apoptosis pathway, and upregulating the expression of PARP, caspase-3, caspase-7, and caspase-8 (Zhong et al., 2022)

I havent read your other replies but many people say when you have your loading doses and during the earlier period of your treatment after loading doses your symptoms appear to get worse before they start to get better

Longitudinal changes in insulin-like growth factor-I, insulin sensitivity, and secretion from birth to age three years in small-for-gestational-age children