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You should not take retatrutide if you have: A personal or family history of medullary thyroid carcinoma Multiple Endocrine Neoplasia syndrome type 2 A history of pancreatitis Severe gastrointestinal disease, including gastroparesis Known hypersensitivity to any component of the drug You should use extreme caution and only proceed under close medical supervision if you have: Gallbladder disease or a history of gallstones Kidney disease, since dehydration from GI side effects can accelerate kidney damage Diabetic retinopathy, as rapid glucose changes can worsen it A history of eating disorders, since appetite suppression this powerful can interact badly with disordered eating patterns Retatrutide is also not approved for use in pregnancy

Over-the-counter antacids containing magnesium or calcium carbonate can provide rapid, short-term relief for mild symptoms

The Benefits of Omega-3s for Heart Health Omega-3 fatty acids are powerful nutrients that can support cardiovascular wellness

These are unapproved drugs that have not gone through clinical trials. Sellers often point to anecdotal claims or early studies in animals or on cells grown in labs, Knoepfler says