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Pregnancy and breastfeeding considerations Tirzepatide is contraindicated during pregnancy and should be discontinued at least 2 months before planned conception due to the long washout period

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The standard for an ingredient to achieve GRAS status requires not only technical demonstration of non-toxicity and safety, but also general recognition of safety through widespread usage and agreement of that safety by experts in the field

(1997) published findings in the Journal of Biological Chemistry demonstrating that IGF-1-mediated signaling through PI3K is essential for myoblast differentiation