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Description

at the peak 12mg/week dose it lasts 2.5 weeks

doi: 10.1038/s41443-022-00605-0 183

Surprisingly, despite the broad systemic anti-inflammatory actions of GLP-1RAs, much (1001000 fold) lower levels of GLP-1R mRNA transcripts are detected in spleen, thymus, lymph nodes and hematopoietic cell lineages, relative to levels of GLP-1R expression in gut IELs [138, 139], suggesting that a substantial proportion of GLP-1 action on immune cells may be indirect

Notably, the median PA time of ~6 days (for cases needing extra review) means many patients wait well over a week to start treatment ( [5] )