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Arginase-1, predominantly expressed in macrophages, and arginase-2, localized in various cells including myofibroblasts, both contribute to proline generation

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Food and Drug Administration (FDA): Ozempic (semaglutide) Prescribing Information American College of Cardiology (ACC): Semaglutide Effects on Cardiovascular Outcomes in People With Overweight or Obesity (SELECT Trial Results) The New England Journal of Medicine (NEJM): Semaglutide and Cardiovascular Outcomes in Patients with Overweight or Obesity Who Do Not Have Diabetes American Heart Association (AHA): Understanding Atrial Fibrillation (AFib) Risk Factors and Symptoms National Institutes of Health (NIH) / PubMed: Glucagon-Like Peptide-1 Receptor Agonists and Cardiovascular Safety Profiling