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Combination of Glucagon-Like Peptide 1 Receptor Agonist and Thiazolidinedione for Mortality and Cardiovascular Outcomes in Patients With Type 2 Diabetes

Tirzepatide's glycemic effect is far better characterized because it is approved for type 2 diabetes

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In liver disease, S100A9 is released during liver necrosis, which binds to NLRP3 on hematopoietic stem cells and myofibroblasts, mediating an increase in the expression of TNF and IL-17 [197], which triggers an inflammatory response and promotes the synthesis of extracellular collagen, ultimately leading to liver fibrosis [198]