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Even though a new diagnosis of pernicious anemia should prompt a stomach endoscopy to check for atrophic gastritis, its important to remember that these antibodies can also show up in individuals with an H pylori infection and other autoimmune conditions

Changes in bowel habits that are severe or persistentsuch as bloody stools, black tarry stools, or diarrhoea lasting more than a few daysrequire medical evaluation to rule out other causes

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In contrast, 1-Cys Prx family members (i.e., human Prx6) lack a resolving cysteine and are likely reduced by GSH (Figure 1)