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Establishment of a pancreatic beta cell line that retains glucose-inducible insulin secretion: special reference to expression of glucose transporter isoforms

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1 Introduction Sulfonylureas are ubiquitously employed as antidiabetic drugs for type 2 diabetes mellitus (T2DM) with characteristics of the deficiency of insulin secretion and/or insulin resistance (IR), a metabolic illness afflicting millions of people worldwide ( ATP ), which are abundantly expressed in -pancreatic cells with an octameric structure composed of four inward rectifier Kir6.2 subunits and four regulatory SUR1 subunits ( 2+ channels (VDCC), in turn causing influx of extracellular Ca 2+ to stimulate insulin release (Sola et al., 2015)

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