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After review of additional data, the 2023 ACC/AHA Guidelines for the Management of Patients with Chronic Coronary Disease published a strong (Class 1, LoE A) recommendation for the use of GLP-1 RA with proven cardiovascular benefits in patients with diabetes and chronic coronary disease to reduce the risk of MACE

Meta-analysis of randomized controlled trials of the effects of probiotics on functional constipation in adults

B., Lathigara, D

44,45 In a meta-analysis of 48 RCTs including 27,729 participants, the overall incidence of GI adverse events was reported to be 11.6%, with nausea identified as the most common symptom (21.4%)