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Some GLP-1 options have also demonstrated cardiovascular benefits, and newer incretin-based medications include dual-agonists (such as GIP/GLP-1) that work similarly but are not exactly the same drug class

Activation of carbohydrate response element-binding protein (ChREBP) also induces an increase in precursors of DNL and an increase in enzymes that further aggravate hepatic steatosis, especially under exposure to lipogenic substrates (62)

Chen Y, Peng X, Feng Z, Zhang L, Bai J, Li Y, et al

If insufficient, osmotic laxatives such as polyethylene glycol are generally safe and effective as first-line agents per AGA-ACG guidelines