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The results demonstrated clear superiority over placebo across all measured endpoints

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Chemogenetic activation of GLP-1 neurons in NTS suppresses appetite and slows weight gain in obese rats After fluorescently labeling and chemogenetic activating GLP-1 neurons in NTS of obese rats using rAAV, the GLP-1 in the NTS region of rats in the HM3D group was activated (Fig

[9] To be able to confirm possible cardiovascular benefits of DPP-4 inhibitors requires large, double-blind, randomized trials with formal adjudication of cardiovascular end points