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Therefore, the observed decrease in bone mass in GLP-1R KO mice could be linked to reduced calcitonin secretion [41]

They share 64% sequence identity and differ in their catalytic activities

However, unlike other GH-Secretagogues this pentapeptide doesnt release the same volumes of cortisol, acetylcholine, prolactin and aldosterone For this reason, lpamorelin has been considered the first selective GH which promotes secretion

CONCLUSION The clinical and preclinical data presented at the ACR Convergence 2025 show both the therapeutic potential and the scientific complexity of GLP-1 agonists in OA