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However, significant challenges remain, including the synthesis of stable tripeptides with good tissue penetration, insufficient understanding of their mechanisms of action, the scarcity of studies in larger animal models and human trials, and the lack of direct head-to-head comparisons with larger peptides [75, 95]

Companies worry that adopting international reference pricing may reduce revenue, potentially impacting their ability to invest in research and development for new drugs

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Note: All views are my own and not to be taken as medical advise.