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Phase 2 CagriSema in T2D (Frias et al., 2023): CagriSema produced superior weight loss and glycemic improvement vs either monotherapy over 32 weeks

A gut-selective dose of sitagliptin reduced lipid excursion and increased active GLP-1 levels in Dpp4 EC+/+ mice but not in Dpp4 EC/ mice, although plasma DPP-4 activity was decreased by approximately 20% in both genotypes (Figure 3, AD)

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