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Month-over-month ADM prescribing increased in October, decreased in November, and increased again in December 2025

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The expression and enzymatic activity of IDO can be significantly upregulated by pro-inflammatory cytokines such as TNF-, IL-6, and IFN- (47), and contribute to the regulation of the Treg/Th17 balance (48), thereby linking immune activation status closely with kynurenine production, thereby linking immune activation closely with kynurenine production

The 1.82.4 pound monthly advantage over diet alone (from the Journal of Obesity study) is real, but it's an accelerant, not a replacement for caloric control