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This localization theoretically reduces systemic side effects and cancer concerns compared to long-acting analogs, though local effects may still influence surrounding tissues

In the reduced state, GSH is a major tissue antioxidant that neutralizes reactive oxygen species

In human NEC, endothelial cell proliferation and IGF-1-producing macrophages are decreased in the intestinal villi compared to controls To determine whether endothelial cell proliferation is affected in human NEC tissues, intestinal tissue sections from non-necrotic areas of patients with NEC and controls were stained with antibodies against CD31 and Ki-67